Mixing Melatonin and Tianeptine (gas station heroin)
Caution
Melatonin deepens the opioid's sedation and makes an overdose look like falling asleep.
Do this
Do not use alone, and keep naloxone nearby.
Where the risk isTap for why
What “Caution” means
Carries risk that is worth understanding before combining. Reduce doses and do not use alone.
How the ratings workThe longer explanation
Melatonin deepens the opioid's sedation and makes an overdose look like falling asleep.
Sources (6)
- FDA warns consumers not to purchase or use any tianeptine product due to serious risks. 2025fda.gov
- Gassaway MM et al. The atypical antidepressant and neurorestorative agent tianeptine is a μ-opioid receptor agonist. Transl Psychiatry. 2014nature.com
- El Zahran T et al. Characteristics of Tianeptine Exposures Reported to the National Poison Data System — United States, 2000–2017. MMWR. 2018pmc.ncbi.nlm.nih.gov
- Melatonin Interactions Checker. Drugs.comdrugs.com
- Melatonin + Xanax: Can You Take Them Together?drugs.com
- Melatonin and SSRIsubiehealth.com
Think this is wrong, or know a better source? Send it.
Other names
- Melatonin
- sleep hormone, circadin
- Tianeptine
- gas station heroin, tianaa, zaza red, neptune's fix, pegasus, td red
- Sold as a supplement — at the doses people take, a full opioid
Also searched asmelatonin and gas station heroin, melatonin and tianaa
Related combinations
Melatonin withWhat not to mix with Melatonin →
Tianeptine withWhat not to mix with Tianeptine →
All combinations →Can you mix Melatonin and Tianeptine (gas station heroin)?
MixSafe rates mixing Melatonin and Tianeptine as "Caution" — carries risk that is worth understanding before combining. Reduce doses and do not use alone. Source: MixSafe research. Educational information, not medical advice.