Combination

Mixing Codeine and GHB / GBL

OpioidDepressant
Codeine also called
lean, purple drank, co-codamol, dihydrocodeine
GHB / GBL also called
ghb, gbl, liquid ecstasy
Verdict

Dangerous

The two substances potentiate each other strongly and unpredictably, very rapidly leading to unconsciousness. While unconscious, vomit aspiration is a risk if not placed in the recovery position

Risk / Physical

The risk here is to the body — breathing, heart, temperature or organs. Set limits before you start, because this kind of harm does not announce itself in time to react.

Can you mix Codeine and GHB / GBL?

High risk of death or life-changing injury. Do not combine.

This is a class-level answer, inherited from Opioids. Nothing specific to this exact pair is documented, so treat it as the default for the class rather than a measurement of these two drugs together.

Codeine
Weak, but metabolised unpredictably between people
Source

TripSit drug combination chart, retrieved 2026-08-20. View the dataset.

Checking more than two?

Combinations of three or more carry risks that no pair-by-pair chart can show. The checker rates every pair at once and flags the whole-mix ones on top.

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Rated dangerous. Educational information only, not medical advice. Absence of a documented interaction is not evidence of safety.