Combination

Mixing Benzodiazepines and Ketamine

DepressantDissociative
Benzodiazepines also called
benzodiazepine, benzos, benzo, xanax, alprazolam, valium
Ketamine also called
ket, special k, kitty, kittens
Verdict

Caution

Both substances potentiate the ataxia and sedation caused by the other and can lead to unexpected loss of consciousness at high doses. While unconscious, vomit aspiration is a risk if not placed in the recovery position.

Risk / Headspace

The risk here is to the experience — intensity, panic, thought loops, confusion. Physical harm is unlikely at ordinary doses. Setting, company and dose do most of the work.

Can you mix Benzodiazepines and Ketamine?

Carries risk that is worth understanding before combining. Reduce doses and do not use alone.

Source

TripSit drug combination chart, retrieved 2026-08-20. View the dataset.

Checking more than two?

Combinations of three or more carry risks that no pair-by-pair chart can show. The checker rates every pair at once and flags the whole-mix ones on top.

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Rated caution. Educational information only, not medical advice. Absence of a documented interaction is not evidence of safety.