Mixing Methadone and PCP (angel dust)
Caution
PCP can lower your opioid tolerance, making an overdose more likely. Take less opioid than usual, do not use alone, and keep naloxone nearby.
PCP can reduce opioid tolerance, increasing the risk of overdose
The risk here is to the experience — intensity, panic, thought loops, confusion. Physical harm is unlikely at ordinary doses. Setting, company and dose do most of the work.
Headspace vs physical riskCan you mix Methadone and PCP (angel dust)?
MixSafe rates mixing Methadone and PCP as "Caution" — carries risk that is worth understanding before combining. Reduce doses and do not use alone. No interaction specific to Methadone and PCP is documented; this is the default for Opioids. Source: TripSit drug combination chart, retrieved 2026-08-20. Educational information, not medical advice.
This is a class-level answer, inherited from Opioids. Nothing specific to this exact pair is documented, so treat it as the default for the class rather than a measurement of these two drugs together.
- Methadone
- Long-acting — outlasts its own effects by many hours
- Methadone also called
- dolophine, methadose, done
- PCP also called
- phencyclidine, angel dust, angeldust, wet, sherm
TripSit drug combination chart, retrieved 2026-08-20. View the dataset.
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Checking more than two?
Combinations of three or more carry risks that no pair-by-pair chart can show. The checker rates every pair at once and flags the whole-mix ones on top.
Open this in the checkerRelated combinations
All combinations →Rated caution. Educational information only, not medical advice. Absence of a documented interaction is not evidence of safety.