Combination

Mixing Ketamine and SSRIs

DissociativeAntidepressant
Ketamine also called
ket, special k, kitty, kittens
SSRIs also called
ssri, zoloft, sertraline, lexapro, escitalopram, prozac
Verdict

Low risk, no synergy

Neither substance is expected to meaningfully change the other. Both still carry their own individual risks.

Can you mix Ketamine and SSRIs?

Neither substance is expected to meaningfully change the other. Both still carry their own individual risks.

Source

TripSit drug combination chart, retrieved 2026-08-20. View the dataset.

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Related combinations

Ketamine withWhat not to mix with Ketamine →
SSRIs withWhat not to mix with SSRIs →
All combinations →

Rated low / no synergy. Educational information only, not medical advice. Absence of a documented interaction is not evidence of safety.