Combination

Mixing Codeine (lean) and Kratom

Q: How dangerous is Codeine with Kratom?

Unsafe: Risk of serious physical or psychological harm. Not recommended under any circumstances.

Q: Is it safe to mix lean and Kratom?

MixSafe lists lean under Codeine. That combination is rated "Unsafe". Additive opioid effect with two unpredictable variables stacked: kratom products vary widely in alkaloid content between batches, and codeine's conversion to morphine varies widely between people. Neither dose means what you think it means.

OpioidOpioid

Verdict

Unsafe

Kratom varies between batches and codeine varies between people, so neither dose means what you think. Avoid this combination.

Additive opioid effect with two unpredictable variables stacked: kratom products vary widely in alkaloid content between batches, and codeine's conversion to morphine varies widely between people. Neither dose means what you think it means.

What “Unsafe” means

Risk / Physical

The risk here is to the body — breathing, heart, temperature or organs. Set limits before you start, because this kind of harm does not announce itself in time to react.

Headspace vs physical risk

In an emergency, call 911911 Never Use Alone Poison Control

What to do

Say what was taken and how much.Responders need it, and in most US states Good Samaritan laws protect both of you from drug possession charges when you call for an overdose.
Unresponsive: put them on their side, tilt the head back, and stay until help arrives.Never leave someone alone to “sleep it off”.
Give naloxone (Narcan) if you have it.It is sold over the counter in every US state and does no harm if opioids turn out not to be involved.
Never Use Alone 1-800-484-3731Stays on the line and sends help if you stop responding.
Full steps: what to do if it is already happeningOverdose signs, the recovery position, what to say on the call, and whether you can be charged for making it.
Poison Control 1-800-222-1222Free and 24/7, for “is this bad?” before it becomes an emergency.

Can you mix Codeine (lean) and Kratom?

MixSafe rates mixing Codeine and Kratom as "Unsafe" — risk of serious physical or psychological harm. Not recommended under any circumstances. Source: MixSafe research. Educational information, not medical advice.

Codeine: Weak, but metabolised unpredictably between people
Kratom: Partial agonist — a ceiling other opioids do not have

Codeine also called: lean, purple drank, co-codamol, dihydrocodeine
Kratom also called: mitragynine, mitragyna, mitragyna speciosa, krat

Source

Respiratory effects of oral mitragynine and oxycodone in a rodent model. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9671979/
Dangerous Kratom Drug Interactions: Benzos, Alcohol, and More. Bicycle Health. https://www.bicyclehealth.com/kratom/dangerous-kratom-drug-interactions
The Associations of Kratom (Mitragynine), Opioids, Other Substances, and Sociodemographic Variables to Drug Intoxication-related Mortality. https://pubmed.ncbi.nlm.nih.gov/39560283/
Presence of kratom in opioid overdose deaths: findings from coroner postmortem toxicological report. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10806006/

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Related combinations

Codeine withWhat not to mix with Codeine →

Kratom withWhat not to mix with Kratom →

All combinations →

Rated unsafe. Educational information only, not medical advice. Absence of a documented interaction is not evidence of safety.