Substance
What not to mix with Buprenorphine (Suboxone)
Opioid
Also calledsubutex, suboxone, bupe, bup, buprenorphine/naloxone, zubsolv
Partial agonist — displaces other opioids off the receptor
Summary
Buprenorphine is checked against 40 other substances — 7 dangerous, 7 unsafe and 8 caution.
Dangerous
7- Buprenorphine and CocaineCocaine hides how much the opioid is slowing you down, so you take more; when the cocaine wears off first, breathing can stop. Do not combine. Keep…
- Buprenorphine and DXMTogether they slow breathing and strain the heart and liver, and DXM makes the opioid hit harder. Do not combine. Keep naloxone nearby.
- Buprenorphine and GHB / GBLEach makes the other much stronger, fast and unpredictably, so people pass out quickly. Do not combine. Keep naloxone nearby, and put anyone who…
- Buprenorphine and KetamineTogether they can cause vomiting and unconsciousness. Do not combine. Keep naloxone nearby, and put anyone who passes out on their side.
- Buprenorphine and MXEMXE can make the opioid hit harder. Do not combine. Keep naloxone nearby.
- Buprenorphine and PregabalinHigh risk of death or life-changing injury. Do not combine.
- Buprenorphine and TramadolTramadol raises the seizure risk, and together they can slow breathing. Do not combine. Keep naloxone nearby.
Unsafe
7- Buprenorphine and AlcoholBuprenorphine's ceiling on slowed breathing does not protect you from alcohol; most deaths on buprenorphine involve alcohol or benzos. Avoid this…
- Buprenorphine and BenzodiazepinesThe main cause of death in people taking buprenorphine. Avoid recreational benzos on top, and do not stop a prescribed one abruptly.
- Buprenorphine and DiphenhydramineEach makes the other stronger, raising the risk of memory loss, collapse and unconsciousness. Avoid this combination. Keep naloxone nearby.
- Buprenorphine and FentanylBuprenorphine knocks fentanyl off the receptor and can throw you into sudden, severe withdrawal. If you are starting buprenorphine after fentanyl, do…
- Buprenorphine and MethadoneBuprenorphine can throw anyone with methadone on board into withdrawal. Switching between them needs a prescriber and a taper.
- Buprenorphine and MethamphetamineMeth hides how much the opioid is slowing you, and when it fades, everything you redosed hits at once, often as you fall asleep. Avoid this…
- Buprenorphine and OpioidsBuprenorphine on top of a full opioid can throw you into sudden, severe withdrawal; the other way round, chasing past it leads to overdose. Avoid…
Caution
8- Buprenorphine and AmphetaminesThe stimulant hides how much the opioid is slowing you; if it wears off first, breathing can stop. Take less of each than usual, do not use alone…
- Buprenorphine and CodeineBuprenorphine largely blocks codeine, so the codeine does little. Do not keep escalating it.
- Buprenorphine and KratomBuprenorphine mostly blocks kratom, sometimes with some withdrawal. Less an overdose risk than a wasted dose: on buprenorphine, kratom will not do…
- Buprenorphine and LithiumTogether they add sedation, and dehydration can push lithium levels up. Keep up water, and keep naloxone nearby.
- Buprenorphine and MAOIsWith certain opioids, MAOIs have caused rare but severe and fatal reactions. Take less of each than usual, do not use alone, and keep naloxone nearby.
- Buprenorphine and MephedroneThe stimulant hides how much the opioid is slowing you; if it wears off first, breathing can stop. Take less of each than usual, do not use alone…
- Buprenorphine and Nitrous OxideEach makes the other stronger, so you can lose balance or pass out without warning. Take less of each than usual, do not use alone, and keep naloxone…
- Buprenorphine and PCPPCP can lower your opioid tolerance, making an overdose more likely. Take less opioid than usual, do not use alone, and keep naloxone nearby.
Low / synergy
1Low / no synergy
17Checking more than one?
This page rates Buprenorphine against one substance at a time. Combinations of three or more carry risks that no pair-by-pair list can show — the checker rates every pair at once and flags the whole-mix ones on top.
Open Buprenorphine in the checkerOther opioids
All combinations →Educational information only, not medical advice. Absence of a documented interaction is not evidence of safety. Combination data from the TripSit drug combination chart, retrieved 2026-08-20.