Mixing Buprenorphine and Kratom
- Buprenorphine also called
- subutex, suboxone, bupe, bup, buprenorphine/naloxone
- Kratom also called
- mitragynine, mitragyna, mitragyna speciosa, krat
Caution
Two partial agonists competing for the same receptor. Buprenorphine binds far more tightly, so it largely displaces kratom and you mostly get buprenorphine — often with a stretch of withdrawal on the way there if kratom use has been heavy. Less an overdose risk than a wasted dose and a rough afternoon, but if you are on buprenorphine maintenance, kratom will not do what you want it to.
The risk here is to the body — breathing, heart, temperature or organs. Set limits before you start, because this kind of harm does not announce itself in time to react.
Can you mix Buprenorphine and Kratom?
Carries risk that is worth understanding before combining. Reduce doses and do not use alone.
- Buprenorphine
- Partial agonist — displaces other opioids off the receptor
- Kratom
- Partial agonist — a ceiling other opioids do not have
- Buprenorphine precipitated opioid withdrawal: Prevention and management in the ED setting. https://www.sciencedirect.com/science/article/abs/pii/S0735675722003126
- Buprenorphine-Precipitated Withdrawal Among Hospitalized Patients Using Fentanyl. https://pmc.ncbi.nlm.nih.gov/articles/PMC11437388/
- Practice-Based Guidelines: Buprenorphine in the Age of Fentanyl. SAEM. https://www.saem.org/education/substance-use/practice-based-guidelines-buprenorphine-in-the-age-of-fentanyl
Checking more than two?
Combinations of three or more carry risks that no pair-by-pair chart can show. The checker rates every pair at once and flags the whole-mix ones on top.
Open this in the checkerRelated combinations
All combinations →Rated caution. Educational information only, not medical advice. Absence of a documented interaction is not evidence of safety.