Dangerous
7-OH is not kratom: it lacks the leaf's ceiling on slowed breathing, so this is two strong opioids stacked.
Do not combine. Keep naloxone nearby, and never use alone.
What to do
- Say what was taken and how much.Responders need it, and in most US states Good Samaritan laws protect both of you from drug possession charges when you call for an overdose.
- Unresponsive: put them on their side, tilt the head back, and stay until help arrives.Never leave someone alone to “sleep it off”.
- Give naloxone (Narcan) if you have it.It is sold over the counter in every US state and does no harm if opioids turn out not to be involved.
- Never Use Alone 1-800-484-3731Stays on the line and sends help if you stop responding.
- Full steps: what to do if it is already happeningOverdose signs, the recovery position, what to say on the call, and whether you can be charged for making it.
- Poison Control 1-800-222-1222Free and 24/7, for “is this bad?” before it becomes an emergency.
What “Dangerous” means
High risk of death or life-changing injury. Do not combine.
How the ratings workThe longer explanation
7-OH is sold beside kratom but is not kratom. The leaf has a ceiling on slowed breathing because the body turns only a little of it into 7-OH; these tablets skip that step, and in mice 7-OH slowed breathing more with every dose increase. Stacked on heroin or oxycodone it is two strong opioids. The FDA calls it a potent opioid and has asked for it to be scheduled.
Sources (2)
- Hill R et al. The respiratory depressant effects of mitragynine are limited by its conversion to 7-OH mitragynine. Br J Pharmacol. 2022pmc.ncbi.nlm.nih.gov
- FDA recommends scheduling of 7-OH (7-hydroxymitragynine). HHS, July 2025hhs.gov
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Related combinations
Can you mix 7-OH and Opioids?
MixSafe rates mixing 7-OH and Opioids as "Dangerous" — high risk of death or life-changing injury. Do not combine. Source: MixSafe research. Educational information, not medical advice.