Mixing 7-OH and Codeine (lean)
Dangerous
Two opioids stacked, and 7-OH is far stronger than the kratom it gets compared to.
Do this
Do not combine. Keep naloxone nearby.
Where the risk isTap for why
What to do
- Say what was taken and how much.Responders need it, and in most US states Good Samaritan laws protect both of you from drug possession charges when you call for an overdose.
- Unresponsive: put them on their side, tilt the head back, and stay until help arrives.Never leave someone alone to “sleep it off”.
- Give naloxone (Narcan) if you have it.It is sold over the counter in every US state and does no harm if opioids turn out not to be involved.
- Never Use Alone 1-800-484-3731Stays on the line and sends help if you stop responding.
- Full steps: what to do if it is already happeningOverdose signs, the recovery position, what to say on the call, and whether you can be charged for making it.
- Poison Control 1-800-222-1222Free and 24/7, for “is this bad?” before it becomes an emergency.
What “Dangerous” means
High risk of death or life-changing injury. Do not combine.
How the ratings workThe longer explanation
Two opioids stacked, and 7-OH tablets are far stronger than the kratom people often compare them to.
Sources (4)
- Hill R et al. The respiratory depressant effects of mitragynine are limited by its conversion to 7-OH mitragynine. Br J Pharmacol. 2022pmc.ncbi.nlm.nih.gov
- FDA recommends scheduling of 7-OH (7-hydroxymitragynine). HHS, July 2025hhs.gov
- Codeine Intoxication Associated with Ultrarapid CYP2D6 Metabolism. NEJMnejm.org
- Codeine Therapy and CYP2D6 Genotype. Medical Genetics Summaries, NCBIncbi.nlm.nih.gov
Think this is wrong, or know a better source? Send it.
Other names
- 7-OH
- 7-hydroxymitragynine, 7-hydroxy mitragynine, 7-hydroxy, 7-oh tablets, 7oh tabs
- Concentrated kratom alkaloid sold as tablets — without the leaf's ceiling on slowed breathing
- Codeine
- lean, purple drank, co-codamol, dihydrocodeine
- Weak, but metabolised unpredictably between people
Also searched as7-oh and lean, 7-oh and purple drank
Related combinations
7-OH withWhat not to mix with 7-OH →
Codeine withWhat not to mix with Codeine →
All combinations →Can you mix 7-OH and Codeine (lean)?
MixSafe rates mixing 7-OH and Codeine as "Dangerous" — high risk of death or life-changing injury. Do not combine. Source: MixSafe research. Educational information, not medical advice.