Combination
Mixing Ibuprofen and Methadone
AnalgesicOpioid
- Ibuprofen also called
- advil, motrin, nurofen, nsaid, nsaids
- Methadone also called
- dolophine, methadose, done
Verdict
Low risk, no synergy
No specific interaction is documented. Ibuprofen's standing risks — stomach bleeding and reduced kidney blood flow — apply in any combination, and matter most when dehydrated, not eating, or dosing repeatedly over a long session.
Can you mix Ibuprofen and Methadone?
Neither substance is expected to meaningfully change the other. Both still carry their own individual risks.
- Methadone
- Long-acting — outlasts its own effects by many hours
- Ibuprofen and Alcohol: Is it Safe to Mix NSAIDs and Alcohol? https://alcohol.org/mixing-with/nonsteroidal-anti-inflammatory/
- Mixing NSAIDs with alcohol. GoodRx. https://www.goodrx.com/classes/nsaids/mixing-with-alcohol
- Ibuprofen interactions to avoid. SingleCare. https://www.singlecare.com/blog/ibuprofen-interactions/
Checking more than two?
Combinations of three or more carry risks that no pair-by-pair chart can show. The checker rates every pair at once and flags the whole-mix ones on top.
Open this in the checkerRelated combinations
All combinations →Rated low / no synergy. Educational information only, not medical advice. Absence of a documented interaction is not evidence of safety.