Substance
What not to mix with Ibuprofen (Advil)
Analgesic
Also calledadvil, motrin, nurofen, nsaid, nsaids, naproxen
Summary
Ibuprofen is checked against 40 other substances — 1 unsafe and 3 caution.
Unsafe
1Caution
3- Ibuprofen and AlcoholBoth are hard on the stomach and kidneys, raising the risk of bleeding and kidney injury. Avoid regular use together, and do not take ibuprofen when…
- Ibuprofen and MDMAMDMA already stresses the kidneys, and ibuprofen adds to that. Rehydrate instead of taking ibuprofen ahead of time.
- Ibuprofen and SSRIsTogether they raise the risk of stomach bleeding. If you take an SSRI daily and use ibuprofen often, raise it with your prescriber.
Low / no synergy
36Checking more than one?
This page rates Ibuprofen against one substance at a time. Combinations of three or more carry risks that no pair-by-pair list can show — the checker rates every pair at once and flags the whole-mix ones on top.
Open Ibuprofen in the checkerOther analgesics
All combinations →Educational information only, not medical advice. Absence of a documented interaction is not evidence of safety. Combination data from the TripSit drug combination chart, retrieved 2026-08-20.