Mixing Ibuprofen (Advil) and SSRIs (antidepressants)
Caution
Together they raise the risk of stomach bleeding. If you take an SSRI daily and use ibuprofen often, raise it with your prescriber.
SSRIs deplete platelet serotonin and impair clotting; NSAIDs damage the gastric mucosa. Combined, they measurably increase the risk of upper gastrointestinal bleeding. This is a real and commonly missed interaction — worth raising with a prescriber if you take an SSRI daily and reach for ibuprofen often.
The risk here is to the body — breathing, heart, temperature or organs. Set limits before you start, because this kind of harm does not announce itself in time to react.
Headspace vs physical riskCan you mix Ibuprofen (Advil) and SSRIs (antidepressants)?
MixSafe rates mixing Ibuprofen and SSRIs as "Caution" — carries risk that is worth understanding before combining. Reduce doses and do not use alone. Source: MixSafe research. Educational information, not medical advice.
- Ibuprofen also called
- advil, motrin, nurofen, nsaid, nsaids, naproxen
- SSRIs also called
- ssri, zoloft, sertraline, lexapro, escitalopram, prozac
- Ibuprofen and Alcohol: Is it Safe to Mix NSAIDs and Alcohol? https://alcohol.org/mixing-with/nonsteroidal-anti-inflammatory/
- Mixing NSAIDs with alcohol. GoodRx. https://www.goodrx.com/classes/nsaids/mixing-with-alcohol
- Ibuprofen interactions to avoid. SingleCare. https://www.singlecare.com/blog/ibuprofen-interactions/
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Checking more than two?
Combinations of three or more carry risks that no pair-by-pair chart can show. The checker rates every pair at once and flags the whole-mix ones on top.
Open this in the checkerRelated combinations
All combinations →Rated caution. Educational information only, not medical advice. Absence of a documented interaction is not evidence of safety.