Mixing Ibuprofen (Advil) and Xylazine (tranq)

Carries risk that is worth understanding before combining. Reduce doses and do not use alone.

Nobody has studied xylazine with this, and no specific interaction is known. It is rated Caution rather than low risk because xylazine is barely studied in people and dangerous on its own: deep sedation, slowed breathing, a slow heart and low blood pressure, none of which naloxone reverses. It is almost never taken on purpose; it comes cut into fentanyl, so if you have been exposed to it, look at the fentanyl pair too, and do not use alone.

• What You Should Know About Xylazine. CDCcdc.gov
• Ruiz-Colón K et al. Xylazine intoxication in humans and its importance as an emerging adulterant in abused drugs: a comprehensive review of the literature. Forensic Sci Int. 2014sciencedirect.com
• Friedman J et al. Xylazine spreads across the US: a growing component of the increasingly synthetic and polysubstance overdose crisis. Drug Alcohol Depend. 2022pubmed.ncbi.nlm.nih.gov

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Ibuprofen

advil, motrin, nurofen, nsaid, nsaids, naproxen

Xylazine

tranq, tranq dope, zombie drug, anestesia de caballo, rompun, medetomidine

Animal sedative cut into fentanyl, as is its stronger cousin medetomidine — naloxone reverses neither

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