Mixing SSRIs (antidepressants) and Zolpidem (Ambien)
Caution
Zolpidem's hallucinations can last for hours alongside these antidepressants.
Take zolpidem in bed, and tell whoever prescribes either.
What “Caution” means
Carries risk that is worth understanding before combining. Reduce doses and do not use alone.
How the ratings workThe longer explanation
Hallucinations are a known zolpidem side effect, and in one poison-centre review nine of the ten people whose hallucinations lasted longest (up to seven hours) were taking an antidepressant that blocks serotonin reuptake. Not dangerous in itself, but frightening, and worse if you get up and act on it. Take zolpidem in bed, and tell whoever prescribes either.
Sources (1)
- Elko CJ, Burgess JL, Robertson WO. Zolpidem-associated hallucinations and serotonin reuptake inhibition: a possible interaction. J Toxicol Clin Toxicol. 1998pubmed.ncbi.nlm.nih.gov
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Other names
- SSRIs
- ssri, zoloft, sertraline, lexapro, escitalopram, prozac
- Zolpidem
- ambien, ambien cr, stilnox, edluar, intermezzo, zolpimist
- Works like a benzo, plus sleepwalking and sleep-driving with no memory of it
Related combinations
- AlcoholDangerous
- XylazineDangerous
- GHB / GBLDangerous
- PregabalinDangerous
- OpioidsDangerous
- FentanylDangerous
Can you mix SSRIs (antidepressants) and Zolpidem (Ambien)?
MixSafe rates mixing SSRIs and Zolpidem as "Caution" — carries risk that is worth understanding before combining. Reduce doses and do not use alone. Source: MixSafe research. Educational information, not medical advice.