Mixing Diphenhydramine (Benadryl) and Xylazine (tranq)

Q: How dangerous is Diphenhydramine with Xylazine?

Unsafe: Risk of serious physical or psychological harm. Not recommended under any circumstances.

Q: Is it safe to mix Benadryl and tranq?

MixSafe lists Benadryl under Diphenhydramine and tranq under Xylazine. That combination is rated "Unsafe". Both sedate, and diphenhydramine at higher doses brings delirium, which makes a xylazine overdose hard to tell apart from confusion. Diphenhydramine also speeds the heart while xylazine slows it.

Unsafe

Heavy sedation plus delirium makes an overdose hard to recognise.

Do this

Avoid this combination, and stay with anyone who has taken both.

Where the risk isTap for why

In an emergency, call 911911 Never Use Alone Poison Control

What to do

Say what was taken and how much.Responders need it, and in most US states Good Samaritan laws protect both of you from drug possession charges when you call for an overdose.
Unresponsive: put them on their side, tilt the head back, and stay until help arrives.Never leave someone alone to “sleep it off”.
Never Use Alone 1-800-484-3731Stays on the line and sends help if you stop responding.
Full steps: what to do if it is already happeningOverdose signs, the recovery position, what to say on the call, and whether you can be charged for making it.
Poison Control 1-800-222-1222Free and 24/7, for “is this bad?” before it becomes an emergency.

What “Unsafe” means

Risk of serious physical or psychological harm. Not recommended under any circumstances.

How the ratings work

The longer explanation

Both sedate, and diphenhydramine at higher doses brings delirium, which makes a xylazine overdose hard to tell apart from confusion. Diphenhydramine also speeds the heart while xylazine slows it.

Sources (5)

What You Should Know About Xylazine. CDCcdc.gov
Ruiz-Colón K et al. Xylazine intoxication in humans and its importance as an emerging adulterant in abused drugs: a comprehensive review of the literature. Forensic Sci Int. 2014sciencedirect.com
Friedman J et al. Xylazine spreads across the US: a growing component of the increasingly synthetic and polysubstance overdose crisis. Drug Alcohol Depend. 2022pubmed.ncbi.nlm.nih.gov
Serotonin Syndrome: Mechanisms, Diagnosis, High-Risk Interactionspsychopharmacologyinstitute.com
Diphenhydramine interaction profile. Drugs.comdrugs.com

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Other names

Diphenhydramine: benadryl, dph, sleep aid, zzzquil, unisom, doxylamine
Xylazine: tranq, tranq dope, zombie drug, anestesia de caballo, rompun, medetomidine; Animal sedative cut into fentanyl, as is its stronger cousin medetomidine — naloxone reverses neither

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Related combinations

Diphenhydramine with

What not to mix with Diphenhydramine →

Xylazine with

What not to mix with Xylazine →

All combinations →

Can you mix Diphenhydramine (Benadryl) and Xylazine (tranq)?

MixSafe rates mixing Diphenhydramine and Xylazine as "Unsafe" — risk of serious physical or psychological harm. Not recommended under any circumstances. Source: MixSafe research. Educational information, not medical advice.