Mixing Opioids and SSRIs (antidepressants)
Low risk, no synergy
There have been some case reports of serotonin syndrome in individuals who were given a combination of opioids and SSRIs. Other research has indicated a small increase in overdose risk for people who are prescribed CYP2D6-inhibiting SSRIs (e.g. fluoxetine and paroxetine) with oxycodone. Overall, risk is low with this combination but, as always, be mindful of your consumption.
Can you mix Opioids and SSRIs (antidepressants)?
MixSafe rates mixing Opioids and SSRIs as "Low risk, no synergy" — neither substance is expected to meaningfully change the other. Both still carry their own individual risks. Source: TripSit drug combination chart, retrieved 2026-08-20. Educational information, not medical advice.
- Opioids
- Full agonists — heroin, oxycodone, morphine
- Opioids also called
- opiate, opiates, opioid, heroin, dope, smack
- SSRIs also called
- ssri, zoloft, sertraline, lexapro, escitalopram, prozac
TripSit drug combination chart, retrieved 2026-08-20. View the dataset.
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Checking more than two?
Combinations of three or more carry risks that no pair-by-pair chart can show. The checker rates every pair at once and flags the whole-mix ones on top.
Open this in the checkerRelated combinations
All combinations →Rated low / no synergy. Educational information only, not medical advice. Absence of a documented interaction is not evidence of safety.