Mixing Tianeptine (gas station heroin) and Xylazine (tranq)
Dangerous
A full opioid plus a sedative naloxone can't reverse, neither labelled reliably.
Do this
Do not combine. Keep naloxone nearby, and never use alone.
Where the risk isTap for why
What to do
- Say what was taken and how much.Responders need it, and in most US states Good Samaritan laws protect both of you from drug possession charges when you call for an overdose.
- Unresponsive: put them on their side, tilt the head back, and stay until help arrives.Never leave someone alone to “sleep it off”.
- Give naloxone (Narcan) if you have it.It is sold over the counter in every US state and does no harm if opioids turn out not to be involved.
- Never Use Alone 1-800-484-3731Stays on the line and sends help if you stop responding.
- Full steps: what to do if it is already happeningOverdose signs, the recovery position, what to say on the call, and whether you can be charged for making it.
- Poison Control 1-800-222-1222Free and 24/7, for “is this bad?” before it becomes an emergency.
What “Dangerous” means
High risk of death or life-changing injury. Do not combine.
How the ratings workThe longer explanation
Tianeptine is a full opioid at the doses people take, and xylazine adds a sedative naloxone cannot reverse. Neither comes with labelling you can trust.
Sources (7)
- Choi S, Irwin MR, Kiyatkin EA. Xylazine effects on opioid-induced brain hypoxia. Psychopharmacology. 2023link.springer.com
- Watkins JM et al. Xylazine exacerbates fentanyl-induced respiratory depression and prevents rescue by naloxone in mice. Psychopharmacology. 2026pmc.ncbi.nlm.nih.gov
- What You Should Know About Xylazine. CDCcdc.gov
- Friedman J et al. Xylazine spreads across the US. Drug Alcohol Depend. 2022pubmed.ncbi.nlm.nih.gov
- FDA warns consumers not to purchase or use any tianeptine product due to serious risks. 2025fda.gov
- Gassaway MM et al. The atypical antidepressant and neurorestorative agent tianeptine is a μ-opioid receptor agonist. Transl Psychiatry. 2014nature.com
- El Zahran T et al. Characteristics of Tianeptine Exposures Reported to the National Poison Data System — United States, 2000–2017. MMWR. 2018pmc.ncbi.nlm.nih.gov
Think this is wrong, or know a better source? Send it.
Other names
- Tianeptine
- gas station heroin, tianaa, zaza red, neptune's fix, pegasus, td red
- Sold as a supplement — at the doses people take, a full opioid
- Xylazine
- tranq, tranq dope, zombie drug, anestesia de caballo, rompun, medetomidine
- Animal sedative cut into fentanyl, as is its stronger cousin medetomidine — naloxone reverses neither
Also searched asgas station heroin and tranq, tianaa and tranq, gas station heroin and tranq dope, tianaa and tranq dope
Related combinations
Tianeptine withWhat not to mix with Tianeptine →
Xylazine with
All combinations →- KetamineDangerous
- MXEDangerous
- AlcoholDangerous
- BenzodiazepinesDangerous
- ZolpidemDangerous
- GHB / GBLDangerous
Can you mix Tianeptine (gas station heroin) and Xylazine (tranq)?
MixSafe rates mixing Tianeptine and Xylazine as "Dangerous" — high risk of death or life-changing injury. Do not combine. Source: MixSafe research. Educational information, not medical advice.