Mixing Kratom and SSRIs (antidepressants)
Caution
Some SSRIs raise kratom levels, so your usual dose can hit harder, and serotonin syndrome is possible. Take less kratom than usual.
Two problems at once. Several SSRIs inhibit CYP2D6, which shifts how mitragynine is cleared and can raise levels from an unchanged dose. Kratom is also mildly serotonergic, so serotonin toxicity is a real if uncommon risk. Practically, the usual outcome is that a familiar dose hits harder than it used to.
The risk here is to the body — breathing, heart, temperature or organs. Set limits before you start, because this kind of harm does not announce itself in time to react.
Headspace vs physical riskCan you mix Kratom and SSRIs (antidepressants)?
MixSafe rates mixing Kratom and SSRIs as "Caution" — carries risk that is worth understanding before combining. Reduce doses and do not use alone. Source: MixSafe research. Educational information, not medical advice.
- Kratom
- Partial agonist — a ceiling other opioids do not have
- Kratom also called
- mitragynine, mitragyna, mitragyna speciosa, krat
- SSRIs also called
- ssri, zoloft, sertraline, lexapro, escitalopram, prozac
- Respiratory effects of oral mitragynine and oxycodone in a rodent model. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9671979/
- Dangerous Kratom Drug Interactions: Benzos, Alcohol, and More. Bicycle Health. https://www.bicyclehealth.com/kratom/dangerous-kratom-drug-interactions
- The Associations of Kratom (Mitragynine), Opioids, Other Substances, and Sociodemographic Variables to Drug Intoxication-related Mortality. https://pubmed.ncbi.nlm.nih.gov/39560283/
- Presence of kratom in opioid overdose deaths: findings from coroner postmortem toxicological report. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10806006/
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All combinations →Rated caution. Educational information only, not medical advice. Absence of a documented interaction is not evidence of safety.