Mixing SSRIs (antidepressants) and Tianeptine (gas station heroin)

Low risk, no synergy

Neither substance is expected to meaningfully change the other. Both still carry their own individual risks.

Do this

Treat each one as if you had taken it alone: its own dose, its own risks.

Reported

There have been some case reports of serotonin syndrome in individuals who were given a combination of opioids and SSRIs. Other research has indicated a small increase in overdose risk for people who are prescribed CYP2D6-inhibiting SSRIs (e.g. fluoxetine and paroxetine) with oxycodone. Overall, risk is low with this combination but, as always, be mindful of your consumption.

General answer for Opioids: nothing specific to these two is documented.

What “Low risk, no synergy” means

Neither substance is expected to meaningfully change the other. Both still carry their own individual risks.

How the ratings work
Sources (1)

Think this is wrong, or know a better source? Send it.

Other names
SSRIs
ssri, zoloft, sertraline, lexapro, escitalopram, prozac
Tianeptine
gas station heroin, tianaa, zaza red, neptune's fix, pegasus, td red
Sold as a supplement — at the doses people take, a full opioid
Also searched asantidepressants and gas station heroin, zoloft and gas station heroin, antidepressants and tianaa, zoloft and tianaa
Add a third substance in the checker

Related combinations

SSRIs withWhat not to mix with SSRIs →
Tianeptine withWhat not to mix with Tianeptine →
All combinations →

Can you mix SSRIs (antidepressants) and Tianeptine (gas station heroin)?

MixSafe rates mixing SSRIs and Tianeptine as "Low risk, no synergy" — neither substance is expected to meaningfully change the other. Both still carry their own individual risks. No interaction specific to SSRIs and Tianeptine is documented; this is the default for Opioids. Source: TripSit drug combination chart, retrieved 2026-08-20. Educational information, not medical advice.

This is a class-level answer, inherited from Opioids. Nothing specific to this exact pair is documented, so treat it as the default for the class rather than a measurement of these two drugs together.