Mixing Advil PM and LSD (acid)
Caution
Carries risk that is worth understanding before combining. Reduce doses and do not use alone.
Can you take Advil PM with LSD?
Advil PM contains ibuprofen and diphenhydramine. The most concerning part is Advil PM (Diphenhydramine) with LSD: beyond an ordinary 25–50 mg dose of diphenhydramine, LSD makes its delirium worse and adds heart strain. Keep diphenhydramine to that dose. MixSafe rates Advil PM with LSD as "Caution" — carries risk that is worth understanding before combining. Reduce doses and do not use alone. Sources: the Drug Facts labels on DailyMed, the TripSit combination chart and MixSafe research. Educational information, not medical advice.
What is in it
- Advil PM
- Ibuprofen + Diphenhydramine.
Ingredient by ingredient
Advil PM (Diphenhydramine) + LSDCaution
Beyond an ordinary 25–50 mg dose of diphenhydramine, LSD makes its delirium worse and adds heart strain. Keep diphenhydramine to that dose.
At 25-50mg, DPH may assist with side effects of the LSD such as nausea and anxiety. At higher dosages, the combination of a deliriant (DPH) and LSD is cautioned against. LSD is likely to increase the deliriant and negative effects of DPH, in addition to increasing the risk of severe injury and mental trauma. LSD and DPH at recreational dosages have additional cardiac concerns such as vasoconstriction, tachycardia, hypertension, which in combination may be exacerbated.
Source: TripSit drug combination chart
Advil PM (Ibuprofen) + LSDLow risk, no synergy
No interaction is documented, but ibuprofen is still hard on the stomach and kidneys, more so after hours without eating or drinking. Eat something and drink water before you take it.
No specific interaction is documented. Ibuprofen's standing risks — stomach bleeding and reduced kidney blood flow — apply in any combination, and matter most when dehydrated, not eating, or dosing repeatedly over a long session.
Sources: Ibuprofen and Alcohol: Is it Safe to Mix NSAIDs and Alcohol? · Mixing NSAIDs with alcohol. GoodRx · Ibuprofen interactions to avoid. SingleCare
- Advil PM, Drug Facts label. DailyMed. https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=658fc201-47c9-6a6d-8af9-6208298d43b4
Ingredient lists checked 2026-09-27. Formulas change and store brands differ, so the Drug Facts box on your own packet is the final word.
Think this is wrong, or know a better source? Send it.
Checking more than two?
The checker reads every ingredient in every box at once, and flags anything you would be taking twice.
Open this in the checker